Overview
Wide variety of different sensing applications from small drug molecules to large proteins. Ligand/receptor binding study is fundamental for understanding molecular recognition in biology. The whole immune system is based upon it, as well as the blood coagulation cascade, signalling transduction between and within cells.
Applications notes
Label-free immunosensor for HSP70 detection
Label-free immunosensor for herbicide trifluralin detection
Determination of TNFa concentration in human serum
Label-free immunosensor for Aflatoxin B1
Related publications
- Grieshaber D, Reimhult E, Voros J, “Enzymatic Biosensors towards a Multiplexed Electronic Detection System for Early Cancer Diagnostics” Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 1: 402 – 405, Jan. 2007
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- Adányi N, Levkovets I A, Rodriguez-Gil S, Szendrı I, Ronald A, Váradi M, “Development of immunosensor based on OWLS technique for determining aflatoxin B1 and ochratoxin A”, Biosensors 2004, 24-26 May, 2004, Granada, Spain
- Váradi M, Adányi N, Kun Sz, Rezessy-Szabó J, Levkovets I A, Szendrı I, “Development of amperometric biosensor and of OWLS based immunosensor for determining biogenic amines in fermented juices”, Biosensors 2004, 24-26 May, 2004, Granada, Spain
- Kim N, Park I-S, “Development of optical grating coupler biosensor immobilized with Salmonella antibody”, Biosensors 2004, 24-26 May, 2004, Granada, Spain Nagel T, Schmidt PM, Heise C, Ehrentreich-Förster E, Singh M, Bier F F, “Label free detection of tuberculosis infection in blood serum” Biosensors 2004, 24-26 May, 2004, Granada, Spain
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- Székács A, Trummer N, Adányi N, Váradi M, Szendro I, “Development of a non-labeled immunosensor for the herbicide trifluralin via optical waveguide lightmode spectroscopic detection” Analytica Chimica Acta 487 (1): 31-42, July 2003
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- Horvath R, Kerekgyarto T, Csucs G, Gaspar S, Illyes P, Ronto G, Papp E, “The effect of UV irrradiation on uracil thin layer measured by optical waveguide lightmode spectroscopy.” Biosensors & Bioelectronics 2000.
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- Szendro I, “Integrated Optical Chemical and Biochemical sensors”, Advanced Study Course on Optical Chemical Sensors, Neusiedl am See, Austria, 27-29 september 1999
- Bilitewski U, Bier F F, Brandenburg A, “Immunobiosensors based on grating couplers”, in K. R. Rogers and A. Mulchandani, “Affinity Biosensors-Techniques and Protocols”, Human Press, Totowa, 121-134, 1998
- Piehler J, Brandenburg A, Brecht A, Wagner E, Gauglitz G, “Characterisation of grating couplers for affinity based pesticide sensing”, Applied Optics (1997)
- Lukosz W, “Integrated-optical and surface-plasmon sensors for direct affinity sensing. Part II: Anisotropy of adsorbend or bound protein adlayers”, Bosensors & Bioelectronics 12 , 175-184, 1997
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- Hungarian-Korean seminar: Integrated circuits and devices, edited by E. Czoboly, Budapest, 301-310, 1997
- Piehler J, Brandenburg A, Brecht A, Wagner E, Gauglitz G, “Reflection grating coupler for affinity based pesticide detection”, Proccedings of the 11th European Conference on Solide State Transducers, Eurosensors XI, Warsaw, Poland, 1437-1440, 1997
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- Makower A, Barmin A, Morzunova T, Eremenko A, Kurochkin I, Bier F F, Scheller F W, “Affinity enzymometric assay for detection of phosphororganic compounds”, Analytica Chemica Acta 357, 13-20, 1997
- Brandenburg A, Polzius R, Bier F, Bilitewski U, Wagner E, “Direct observation of affinity reactions by reflected mode operation of integrated optical grating coupler”, Sensors and Actuators B 30, 55 – 59, 1996
- Ramsden J J, “A dosimeter for oligopeptide hormones”, Sensors and Actuators B 30, 107 – 110, 1996
- Bier F F, Stöcklin W F M, E. Ehrentreich-Förster and F.W. Scheller, “Immunosensing of 2,4-dichlorophenoxy acetic acid using biochemical amplification. Influence of organic solvent on binding observed by evanescent field technology”, Proc. SPIE 2504, 153 – 158, 1995
- Ramsden J J, Schubert Wright C, “The interaction between wheat germ agglutinin and membrane incorporated glycophorin A. An optical binding study”, Glycoconjugate Journal 12, 113 – 121, 1995
- Bernard A, Bosshard H R, “Real-time monitoring of anti-gen-antibody recognition on a metal oxide surface by an optical grating coupler sensor”, Eur. J. Biochem. 230, 416 – 423, 1995
- Bier F F, Schmid R D, “Real time analysis of competitive binding using grating coupler immunosensors for pesticide detection”, Biosensors and Bioelectronics 9, 125 – 130, 1994
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- Ramsden J J, Schneider P, “Membrane insertion and antibody recognition of a Glycosylphosphatidylinositol-Anchored protein: An optical study”, Biochemistry 32, 523 – 529, 1993
- Jockers R, Bier FF, Schmid R D, “Specific binding of photosynthetic reaction centres to herbicide-modified grating couplers”, Analytica Chimica Acta 280, 53 – 59, 1993
- Polzius R, Bier F F, Bilitewski U, Jäger V, Schmid R D, “On-line monitoring of monoclonal antibodies in animal cell culture using a grating coupler”, Biotechnology and Bioengineering 42, 1287 – 1292, 1993
- Panayotou G, Waterfield M D, End P, “Riding the evanescent wave”, Current Biology 3, 913 – 915, 1993
- Bier F F, Stöcklein W, Schmid RD, “Direct observation of antiatrazine antibody binding using grating couplers”, GBF-Monographs Vol. 17; Eds. R.D. Schmid and F. Scheller, VCH Weinheim, 205, 1992
- Nellen Ph M, Lukosz W, “Model experiments with integrated optical input grating couplers as direct immunosensors”, Biosensors & Bioelectronics 6, 517 – 525, 1991
- Lukosz W, Clerc D, Ph M Nellen, Stamm Ch, Weiss P, “Output grating couplers on planar optical waveguides as direct immunosensors”, Biosensors & Bioelectronics 6, 227 – 232, 1991
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- Nellen P M, Tiefenthaler K, Lukosz W, “Integrated Optical Input Grating Couplers as Biochemical Sensors”, Sensors and Actuators 15, 285, 1988
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